Oxidation of reduced glutathione by subcellular fractions of rat liver
نویسندگان
چکیده
منابع مشابه
Rat-Liver Mitochondria and other Subcellular Fractions
1. Rat-liver mitochondria showed a decrease in amino acid production after preparation in 0-25m-sucrose containing EDTA (lnm), but an increase in water content. When EDTA was replaced by Mn2+ (Imm) or succinate (lmM), both amino acid production and water content were lowered, whereas preparation in 0-9% potassium chloride caused an increase in both. 2. Amino acid production by rat-liver homogen...
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The localization of various metabolic processes of cells in particulate and soluble intracellular components has been studied intensively (l-3). The effect of added metals on these processes has also received attention (4-l3), but information on the metal content of the cell fractions is limited (14-16). The association of metals with proteins has been divided into two categories on the basis o...
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I. Black-hooded weanling rats were given a copper-deficient diet or diets providing 3 ppm Cu with or without supplements containing combinations of molybdate, sulphate and sulphide salts to provide 35 ppm molybdenum and z pg atoms sulphurlg. Changes in weight and blood haemoglobin concentration were studied during 48 d of treatment. The subcellular distribution of Cu and Mo in the liver was sub...
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The incorporation of glucosamlneJ4C into plasma lipoproteins has been measured in the intact rat, in liver slices, and in the liver microsome fraction. The labeling of lipoprotein was studied in microsome subfractions, both in viva with glucosammeJ4C and in vitro with UDP-N-acetylglucosamineW. After isolation of lipoproteins with the aid of carrier plasma, labeled lipoproteins were found in smo...
متن کاملMolecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions.
Fotemustine is a clinically used DNA-alkylating 2-chloro-ethyl-substituted N-nitrosourea, which sometimes shows signs of haematotoxicity and reversible liver and renal toxicity as toxic side-effects. Mechanistic data on these side-effects are scarce and incomplete. In this study, firstly the cytotoxicity of fotemustine in freshly isolated rat hepatocytes was investigated and secondly the metabo...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1966
ISSN: 0006-2936
DOI: 10.1042/bj1000095